n The female of larger species of mammal, including bovines, moose, whales, seals, hippos, rhinos, manatees, and elephants.
n (derogatory|informal) A woman who is considered despicable in some way, especially one considered to be fat, lazy, ugly, argumentative, mean or spiteful.
n (informal) A conniption fit or hissy fit; a state of agitation (context|only in the phrase 'have a cow').