n (context|sometimes considered offensive) The disadvantage itself, in particular physical or mental disadvantages of people.
n A race, for horses or men, or any contest of agility, strength, or skill, in which there is an allowance of time, distance, weight, or other advantage, to equalize the chances of the competitors.
n (obsolete|card game) An old game at cards. - Pepys
v (transitive) To encumber with a handicap in any contest.
v (transitive|by extension) To place at disadvantage.