v (colloquial) To ruin; wreck; mess up; screw up; sometimes as a bowdlerized substitution for (term|fuck up).
v (obsolete|transitive|and|intransitive|dialect|West England|and|Australia) To give up; to abandon (something); to jig up, throw up, chuck up (give up, concede); to discontinue; to leave a job, break a contract; to jack in